NL-OMON45119已完成不适用
Executive and social functioning in early- and continuously-treated patients with PKU: A follow-up study 10 years later - Executive and social functioning in PKU patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2 至 99（—）
入选标准
- •- Patients meet NIH-diagnostic criteria for Hyperphenylalaninemia (HPA) or Phenylketonuria
- •- PKU patients were treated early (within one month after birth) and continuously (at least until age 12)
- •- Born after 1974 (start national screening PKU) and minimum age of 7 years at time of study
- •- Dutch speaking
- •- PKU patients who use or used Tetrahydrobiopterin (BH4) will not be excluded, but the use of this type of medication (which is being used to treat BH4-responsive HPA/PKU-patients) will be taken into account for statistical analyses (e.g. will be introduced as a covariate in between-group comparisons)
排除标准
- •- Mental retardation that has been diagnosed by the clinical centre, or if the IQ is below 80 (after assessment)
- •- Lack of fluency in Dutch
- •- Use of medication other than Tetrahydrobiopterin that may affect cognitive functioning
- •- Medical illnesses other than PKU with known effects on cognitive and social functioning
研究者
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