Executive and social functioning in patients with Tyrosinemia Type 1 - Executive and social functioning in Tyrosinemia Type 1

niversitair Medisch Centrum Groningen0 个研究点目标入组 36 人开始时间: 待定最近更新: 2024年4月29日

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•General inclusion criteria for recruitment of HT1 patients:
•- Patients meet NIH-diagnostic criteria for Hereditary Tyrosinemia Type 1 (HT1)
•- Patients are treated with NTBC alone or with a diet as well, or patients received orthotopic liver transplantation (OLT)
•- Minimum age of 7 years at time of study
•- IQ >= 80 (if unknown, this will be assessed)
•- Patients have not participated in neuropsychological studies in the last 6 months
•- Native speaker;General inclusion criteria for recruitment of controls:
•- Controls are healthy
•- Minimum age of 7 years at time of study
•- IQ >= 80 (if unknown, this will be assessed)
•- Controls have not participated in neuropsychological studies in the last 6 months
•- Native speaker

•General exclusion criteria for recruitment of HT1 patients:
•- Mental retardation that has been diagnosed by the clinical centre
•- Neurological damage due to the disease, except for acute porphyria attacks
•- Medical illnesses other than HT1 with known effects on cognitive and social functioning
•- Not a native speaker;General exclusion criteria for recruitment of controls:
•- Mental retardation that has been diagnosed by the clinical centre
•- Medical illnesses with known effects on cognitive and social functioning
•- Not a native speaker

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