Primary Immunodeficiencies impacting regulatory T cell biology
Recruiting
- Conditions
- E31.0D84D82D89Autoimmune polyglandular failureOther immunodeficienciesImmunodeficiency associated with other major defectsOther disorders involving the immune mechanism, not elsewhere classified
- Registration Number
- DRKS00017386
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1.Chronic benign lymphoproliferation (i.e. splenomegaly +/- lymphadenopathy at 2 sites without infectious or malignant cause)
AND
2.Autoimmune disease (i.e. AI cytopenia OR inflammatory bowel disease OR CNS inflammatory disease OR interstitial lung disease)
OR
one of the two above manifestions
AND
3.At least one factor indicating a primary immunodeficiency (i.e. infection susceptibility OR additional autoimmune or inflammatory manifestations OR hypogammaglobulinemia OR aberrant immunophenotype OR positive family history OR consanguinity)
Exclusion Criteria
No written informed consent of patient or parents (in case of minors) has been obtained
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detailed analysis of Immunsystem of patients suffering from Treg-PID
- Secondary Outcome Measures
Name Time Method