Study of epigenetics in patients with Rheumatoid lung disease.
Not Applicable
- Conditions
- Health Condition 1: M051- Rheumatoid lung disease with rheumatoid arthritis
- Registration Number
- CTRI/2024/02/062951
- Lead Sponsor
- The Executive Director, All India Institute of Medical Sciences, Rajkot
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients with Rheumatoid arthritis having pulmonary complications. (diagnosis will be based on ACR/EULAR criteria using clinical history, examination, immunological investigation, radiological investigations)
Healthy age and gender matched volunteers without any pulmonary disease, systemic illness or connective tissue disorders.
Exclusion Criteria
Patients with pulmonary manifestations which are not attributable to Rheumatoid arthritis.
Refusal of consent for participation
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of difference in profile of circulatory H3 with various epigenetic modifications in patients with rheumatoid arthritis with pulmonary complications.Timepoint: 0-6 months: Method standardization <br/ ><br>7-22 months: Subject recruitment & biochemical analysis of serum samples. <br/ ><br>22-24 months: Statistical analysis
- Secondary Outcome Measures
Name Time Method Correlation of therapeutic response of ongoing treatment and epigenetic profile of circulatory H3 modifications.Timepoint: 0-6 months: Method standardization <br/ ><br>7-24 months: Subject recruitment, biochemical analysis of serum samples & find out correlation between therapeutic response of ongoing treatment and epigenetic profile of circulatory H3 modifications.