Detection of global methylation and histone acetylation in aggressive variants of thyroid carcinoma by immunohistochemical analysis

Not Applicable

Recruiting

• Conditions: Basic epigenetic events (global methylation and histone acetylation) in aggressive variants of thyroid cancer including anaplastic, medullary and poorly differentiated carcinomas; Thyroid carcinoma, epigenetics, methylation, acetylation

• Registration Number: TCTR20180314001
• Lead Sponsor: Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-14
• Study Completion: 2018-11-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Morphologically verified thyroid cancers, including ATC, MTC and PDTC

Exclusion Criteria

Cases with missing clinical data, samples of inadequate size (less than 5 mm) and
low quality which are not suitable for IHC analysis

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
basic epigenetic events (global methylation and histone acetylation) Cohort of 2004-2015 years Immunohistochemistry (automated scoring)

Secondary Outcome Measures

Name	Time	Method
Comparing methylation and acetylation score Cohort of 2004-2015 years Immunohistochemistry (automated scoring)