Interaction between ventilation strategy, lung volume, and hemodynamics in patients with acute respiratory distress syndrome

Not Applicable

Recruiting

• Conditions: Adult respiratory distress syndrome; J80

• Registration Number: DRKS00033400
• Lead Sponsor: niversitätsmedizin Mannheim

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Moderate to severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 =150 mmHg

Exclusion Criteria

Age < 18 years, contraindications to prone positioning, pregnancy, presence of a cardiac pacemaker and/or implanted defibrillator, and life expectancy < 24 hours.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ung total elastic power and its components (elastic static and elastic dynamic power) normalized to end-expiratory lung volume.<br>The measurements are performed and compared with individualized tidal volume and PEEP settings.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoints are the effects of individualized settings of tidal volume and PEEP on the partitioned respiratory system mechanics (lung and chest wall), end-expiratory lung volume, pulmonary ventilation and perfusion distribution, hemodynamics and gas exchange.