A clinical trial to study the effect of addition of oral zinc or placebo with local anesthetic lignocaine over vocal cords in reducing the postoperative sore throat after general anesthesia.
Phase 3
- Conditions
- Health Condition 1: - Health Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2024/03/063725
- Lead Sponsor
- I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients aged 18 to 65 years.
2.Patients with American Society of Anesthesiologists (ASA) physical status [19] I to II.
3.Patients with Mallampatti grade (MPG) I & II
4.Patients scheduled to undergo elective surgery of 4 hours duration who requires general endotracheal anaesthesia.
Exclusion Criteria
1.Patients with pre-existing steroid or non-steroidal anti-inflammatory drug use.
2.Patients who will be on Zinc supplements.
3.Patients having history of preoperative sore throat or recent upper airway infection, asthma, chronic obstructive pulmonary disease.
4.Patients with known or anticipated difficult airway.
5.Patients with known allergy to study drug.
6.Known smoker.
7.Pregnant and lactating women.
8.Patients not willing to give consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method occurrence of postoperative sore throat after tracheal extubationTimepoint: At 0 min , 1st hour , 2nd hour , 4th hour , 6 th hour and 24hrs
- Secondary Outcome Measures
Name Time Method 1.Severity of postoperative sore throat. <br/ ><br> 2.Severity of post-operative cough <br/ ><br>3.The severity postoperative hoarseness <br/ ><br>Timepoint: at 0, 1, 2, 4, 6 and 24 hours after tracheal extubation