Studies on skin damage by UVC at 233 nm compared to UVB in vivo
Not Applicable
- Conditions
- healthy subjects
- Registration Number
- DRKS00028055
- Lead Sponsor
- Charité – Universitätsmedizin Berlin,Department of Dermatology, Venerology and Allergology,Center of Experimental and Applied Cutaneous Physiology (CCP)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
male and female volunteers =18 years without skin diseases
written informed consent
skin type I–III (Fitzpatrick)
Informed about the goal and nature of the study
no intensive sun exposure on the skin sites to be irradiated (lower back) in the 14 days prior to the examinations
Exclusion Criteria
minors
breastfeeding women and women with known pregnancy
known skin diseases
skin type >III (Fitzpatrick)
intensive sun exposure on the skin sites to be irradiated (lower back) in the 14 days prior to the examinations
subjects who cannot make decisions independently
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The classical skin parameters erythema formation, transepidermal water loss, skin hydration, elasticity and pH, as well as the activation state of mast cells and macrophages in the skin 24 h after Far-UVC irradiation of 60 mJ/cm² 233 nm do not change.
- Secondary Outcome Measures
Name Time Method o or negligible DNA damage in the skin occurrs after Far-UVC irradiation of 60 mJ/cm² 233 nm.