Dynamics of the stress response in acute and prolonged critical illness

Not Applicable

Completed

• Conditions: Critical illness; Not Applicable

• Registration Number: ISRCTN14587520
• Lead Sponsor: Katholieke Universiteit Leuven (Belgium)

Brief Summary

2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30374692 results

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-07
• Study Completion: 2018-05-10
• Last Update Posted: 5 September 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For patients:
1. Critically ill patients at the surgical or medical intensive care units, with ongoing intensive care dependency, a stable condition for at least 48h, and an expected stay in ICU for at least 48h
2. Age =18 years

For healthy volunteers:
1. Age-, gender- and BMI-matched to the included patients

Exclusion Criteria

For patients:
1. Predisposing factors of adrenal insufficiency
1.1. Cerebral disease with intracranial hypertension threatening the neuroendocrine system
1.2. Pituitary disorders including (pan)hypopituitarism
1.3. Known adrenal disease (Cushing’s syndrome or Addison’s disease)
1.4. Chronic treatment with glucocorticoids, other steroids or anti-steroid chemotherapy within the last 3 months
1.5. IV administration of glucocorticoids within the last 72 hours
1.6. Use of etomidate within the last 72 hours
1.7. Use of azoles within the last 7 days
1.8. Other drugs predisposing to adrenal insufficiency: phenytoin, rifampicin, glitazones, imipramin, phenothiazine, phenobarbital
2. Patients known to be pregnant or nursing
3. No arterial line or central venous catheter in place
4. Ethical restrictions
4.1. Moribund
4.2. Declined participation

For healthy volunteers:
1. Recent history of treatment with HPA-axis interfering drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified