Hypoperfusion and activated protein C after out of hospital cardiac arrest: triggers for hyperfibrinolysis

Completed

• Conditions: cardiac arrest; cardiopulmonary arrest; 10019280

• Registration Number: NL-OMON37362
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Adult patients
Admitted to shock room by paramedic ambulance (presence of registration files for cardiopulmonary resuscitation)
Return of spontaneous circulation (ROSC) after out of hospital cardiac arrest
Presence of hyperfibrinolysis

Exclusion Criteria

Patients with hemostatic deficiencies or previous hemostatic problems
Deceased patients upon ED arrival
Absence of a peripheral intravenous catheter
Patients using vitamine K antagonists, clopidogrel or dabigatran

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/endpoint:<br /><br><br /><br>Hypoperfusion as reflected by cerebral tissue hemoglobin oxygenation and the<br /><br>incidence and onset time of hyperfibrinolysis in OHCA patients</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters/endpoints<br /><br><br /><br>- Blood coagulation and fibrinolytic parameters.<br /><br>- Patient demographics including age, gender, body mass index, smoking.<br /><br>- Cause of out of hospital cardiac arrest.<br /><br>- Medication use<br /><br>- Time to cardiopulmonary resuscitation, duration of cardiopulmonary<br /><br>resuscitation, body temperature upon arrival.<br /><br>- Lowest temperature during post-resuscitation cooling, duration of cooling.<br /><br>- Mortality.</p><br>