Effects of Nopal Fractions on Postprandial Glucose Regulation and Appetite Variables in Healthy Humans

Not Applicable

Completed

• Conditions: Glucose Tolerance; Appetite Sensations
• Interventions: Dietary Supplement: Test product without the active components; Dietary Supplement: Nopal fractions

• Registration Number: NCT04439630
• Lead Sponsor: Lund University

Brief Summary

Postprandial effects of Nopal fractions on glucose and appetite regulation will be investigated in healthy humans, in a randomised controlled crossover trial

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-18
• Study First Submitted QC: 2020-06-18
• Study First Posted: 2020-06-19
• Study Start: 2020-07-01
• Primary Completion: 2020-08-01
• Study Completion: 2020-08-01
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-02
• Last Update Posted: 2020-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy
• non-smokers
• diet accordance with the Nordic Nutrition Recommendations
• BMI: 18.5-25 kg/m2

Exclusion Criteria

• metabolic disorders
• food allergies
• no probiotics or other food /supplement which may interfere with the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
reference	Test product without the active components	Test product without the active components
Nopal fraction 1	Nopal fractions	Fraction one out of two possible
Nopal fraction 2	Nopal fractions	Fraction two out of two possible

Primary Outcome Measures

Name	Time	Method
postprandial insulin concentrations	0-180 min	effects on serum insulin concentrations after intake of test products at breakfast. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.
postprandial glucose tolerance	0-180 min after start of the meal	effects on postprandial glucose tolerance after intake of test products at breakfast. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.

Secondary Outcome Measures

Name	Time	Method
subjective appetite variables	0-180 min	Subjective appetite variables (hunger, satiety, desire to eat) after intake of test products at breakfast, using a 100 mm Visual Analogue Scale (VAS) on a white paper. Except from a center mark in the center of the scale there was no other visible marks. Measurements were performed at fasting (time = 0 min) and at 15, 30, 45, 60, 90, 120, 150 and 180 min.

Trial Locations

Locations (1)

Food Technology, engineering and Nutrition, LTH, Lund University; 🇸🇪 Lund, Sweden