Advanced Glycation End products in Children with Obesity and Children with Diabetes Mellitus type 1

Completed

• Conditions: obesitas; Advanced Glycation End products. glycated proteins; 10018424

• Registration Number: NL-OMON40284
• Lead Sponsor: Sint Antonius Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

-<24 years of age
AND
-Diabetes Mellitus Type 1 OR Obesity

Exclusion Criteria

-A dark-colored skin with a reflectance below 12%, measured with the AGE Reader.
-Use of sun protection cream up to 5 days or self tanner up to 14 days before examination.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> the level of sAF in children and young adults with T1DM and in children with<br /><br>obesity with or without T2DM and the correlation between sAF levels and HbA1c<br /><br>in children and young adults with T1DM and in children with obesity with or<br /><br>without T2DM.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>correlation between sAF levels and age.<br /><br>correlation between sAF levels and body mass index (BMI).<br /><br>correlation between sAF levels and duration of T1DM<br /><br>correlation between sAF levels and duration of obesity (if traceable).<br /><br>correlation between sAF levels and duration of T2DM.<br /><br>correlation between sAF levels and cardiovascular parameters<br /><br>correlation between sAF levels and lipid profile.<br /><br>correlation between sAF levels and renal function.<br /><br>correlation between sAF levels and use of medication for co-morbidities.<br /><br><br /><br>correlation between sAF levels and fasting plasma glucose (FPG).<br /><br>correlation between sAF levels and fasting plasma insulin (FPI).<br /><br>correlation between sAF levels and insulin resistance (IR).<br /><br>correlation between sAF levels and impaired glucose tolerance (IGT).</p><br>