Correlation Between OCT and Mf-ERG Findings With BCVA in Patients With Macular Dystrophy

Not yet recruiting

• Conditions: Macular Dystrophy

• Registration Number: NCT07171541
• Lead Sponsor: New Valley University

Brief Summary

Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in patients with macular dystrophy.

Detailed Description

Macular dystrophies cause progressive central vision loss, but the relationship between structural retinal changes (OCT) and functional deficits (mf-ERG) with visual outcomes remains poorly understood. Current clinical assessment relies primarily on visual acuity, which inadequately reflects retinal damage or predicts disease progression. This knowledge gap limits prognostic accuracy and optimal patient management. Recent advances in OCT and mf-ERG technology provide an opportunity to establish robust structure-function correlations. Understanding these relationships will enhance patient care through improved prognosis, standardized monitoring protocols, and better clinical trial outcome measures for macular dystrophy patients.

Study Timeline

• Study First Submitted: 2025-08-27
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-08
• Last Update Submitted: 2025-09-08
• Study First Posted: 2025-09-12
• Last Update Posted: 2025-09-12
• Study Start: 2025-09-20
• Primary Completion: 2025-11-20
• Study Completion: 2025-12-20

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• All patients diagnosed with macular dystrophy in Tiba Eye Centre, Egypt, Assiut, during the period of the study

Exclusion Criteria

• The patients diagnosed with macular dystrophy refuse to contribute to the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BCVA (best corrected visual acuity)	Day 1/month 3	BCVA was recorded in 30 eyes of 30 patients with macular dystrophy.
CMT (central macular thickness) μm Central macular thickness measurement using optical coherence tomography	Day1/month 3	CMT (central macular thickness) in μm in 30 eyes of 30 patients with macular dystrophy Central macular thickness measurement using optical coherence tomography.
mf-ERG amplituide nV/deg2	Day 1/month 6	mf-ERG amplitude nV/deg² in 30 eyes of 30 patients with macular dystrophy multifocal electroretinogram amplitude measurement using the mf-ERG machine