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临床试验/NCT07171541
NCT07171541尚未招募不适用

Correlation Between Optical Coherence Tomography and Multifocal Electroretinogram Findings With Visual Acuity in Patients With Macular Dystrophy

New Valley University0 个研究点目标入组 30 人开始时间: 2025年9月20日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
主要终点
BCVA (best corrected visual acuity)

研究概览

简要总结

Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in patients with macular dystrophy.

详细描述

Macular dystrophies cause progressive central vision loss, but the relationship between structural retinal changes (OCT) and functional deficits (mf-ERG) with visual outcomes remains poorly understood. Current clinical assessment relies primarily on visual acuity, which inadequately reflects retinal damage or predicts disease progression. This knowledge gap limits prognostic accuracy and optimal patient management. Recent advances in OCT and mf-ERG technology provide an opportunity to establish robust structure-function correlations. Understanding these relationships will enhance patient care through improved prognosis, standardized monitoring protocols, and better clinical trial outcome measures for macular dystrophy patients.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • All patients diagnosed with macular dystrophy in Tiba Eye Centre, Egypt, Assiut, during the period of the study

排除标准

  • The patients diagnosed with macular dystrophy refuse to contribute to the study.

结局指标

主要结局

BCVA (best corrected visual acuity)

时间窗: Day 1/month 3

BCVA was recorded in 30 eyes of 30 patients with macular dystrophy.

CMT (central macular thickness) μm Central macular thickness measurement using optical coherence tomography

时间窗: Day1/month 3

CMT (central macular thickness) in μm in 30 eyes of 30 patients with macular dystrophy Central macular thickness measurement using optical coherence tomography.

mf-ERG amplituide nV/deg2

时间窗: Day 1/month 6

mf-ERG amplitude nV/deg² in 30 eyes of 30 patients with macular dystrophy multifocal electroretinogram amplitude measurement using the mf-ERG machine

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Asmaa Kamel Ahmed Hassan

Dr.principle investigators/ Lecture of ophthalmology ,faculty of medicine , New Valley University

New Valley University

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