The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children

Not Applicable

• Conditions: Molluscum Contagiosum
• Interventions: Drug: KOH 10 %; Drug: Acyclovir

• Registration Number: NCT04476186
• Lead Sponsor: Dalia Mahran

Brief Summary

The investigators will study the effectiveness of acyclovir in the treatment of molluscum contagiosum in assiut university hospital - dermatological out patient clinic the treatment group will receive acyclovir 200 mg 5 times per day the controlled group will receive local KOH solution

Detailed Description

Study population:

Site of the study: The outpatient dermatological clinic in Assiut university hospital.

Participants: children (2 -16) years' old attending dermatological clinic in Assiut university hospital and their parents.

Methodology in details:

1. We will use the social media as " Facebook" to invite patient to visit the clinic and follow up them due to the protective measures of covid 19.

2. Diagnosis of the patient with molluscum contagiosum according to the clinical picture

3. Collecting data including personal and clinical data through interviewing the patient and his or her parents

4. Pictures of the lesions will be taken before and after treatment after patient consent.

5. We will Randomly assigning the patient to either treatment group or controlled group according to simple random table

6. Prescribing the treatment according to the patient group

7. Follow up of the patient after 1 weak and each week according to the response to treatment or presence of complication

Inclusion criteria:

Children (5 -15) years old with Molluscum contagiosum.

Exclusion criteria:

1. Molluscum contagiosum with Inflamed spot

2. Known immune compromised children

3. Molluscum lesion in the eye lid.

4. Children with renal impairment.

Study Timeline

• Study Start: 2020-06-15
• Status Verified: 2020-07
• Study First Submitted: 2020-07-06
• Study First Submitted QC: 2020-07-14
• Last Update Submitted: 2020-07-14
• Study First Posted: 2020-07-20
• Last Update Posted: 2020-07-20
• Primary Completion: 2021-12-29
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Children (2 -16) years old with Molluscum contagiosum.

Exclusion Criteria

• Molluscum contagiosum with Inflamed spot Known immune compromised children Molluscum lesion in the eye lid. Children with renal impairment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
controlled group	KOH 10 %	KOH 10 % solution local application with apiece of cotton 2 time per day maximum for 1 month
treatment group	Acyclovir	200 mg of oral acyclovir 5 timed per day for 5 days per week for maximum 1 month

Primary Outcome Measures

Name	Time	Method
The percentage of patient with complete clearance of all molluscum lesions.	3 month for each participant	we will measure the percentage of patient recovered from all lesion

Trial Locations

Locations (1)

Hamdy Gomaa; 🇪🇬 Assiut, New Assiut City, Egypt