The Association Between Monocyte Subsets and Coronary Collateral Development in Diabetes Mellitus

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT01671306
• Lead Sponsor: Samsun Education and Research Hospital

Brief Summary

Monocyte heterogeneity in peripheral blood seems to be important in coronary collateral development in non-diabetic patients with stable coronary artery disease. Our aim in this study is to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development in type 2 diabetic patients.

Detailed Description

83 diabetic patients with severe coronary artery disease were enrolled in the study. These patients were investigated according to their collateral development. Monocytes and their subtypes, namely CD14++CD16- and CD14+CD16+ cells were compared in 2 groups

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2011-10
• Study Completion: 2011-10
• Status Verified: 2012-08
• Study First Submitted: 2012-08-18
• Study First Submitted QC: 2012-08-22
• Last Update Submitted: 2012-08-22
• Study First Posted: 2012-08-23
• Last Update Posted: 2012-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

• presence of > 95% stenosis of at least one major coronary artery in their first coronary angiogram.

Exclusion Criteria

• Patients experiencing acute coronary syndrome either with or without ST elevation in the last one month
• Evidence of ongoing infection and inflammation, known malignancy and chronic kidney disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified