Treatment of inflamed dental implants

Not Applicable

Completed

• Conditions: Patients with osseointegrated oral implants with peri-implantitis lesions; Oral Health

• Registration Number: ISRCTN57998865
• Lead Sponsor: niversity of Giessen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2023-03-23
• Study Start: 2023-06-19
• Last Update Posted: 4 July 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

1. Patients with at least one osseointegrated and functionally loaded oral implant
2. Patients with at least one implant with peri-implantitis with local signs of inflammation, i.e. bleeding upon probing w/o suppuration
2.1. Increased probing depths
2.2. Radiographically visible loss of peri-implant bone
3. Removability of the supraconstruction of the implant

Exclusion Criteria

1. Fracture of the implant
2. Malignancies
3. Mobility of the implant
4. Intake of immuno-suppressive drugs
5. Pregnancy
6. Systemic diseases with impact on treatability by local surgical interventions
7. Systemic therapy with bisphosphonates or monoclonal antibodies with impact on bone metabolism
8. Therapy with systemic antibiotics within 3 months before the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peri-implant bleeding measured using a periodontal probe (PCPUNC 15) at baseline and at 4 weeks, and 3, 6 and 12 months after treatment

Secondary Outcome Measures

Name	Time	Method
<br> 1. Peri-implant probing pocket depth measured using a periodontal probe (PCPUNC 15) at baseline and at 4 weeks, and 3, 6 and 12 months after treatment<br> 2. Lack of peri-implant suppuration measured using visual inspection and probing the peri-implant sites at 4 weeks, and 3, 6 and 12 months after treatment<br> 3. Reduction of the peri-implant bony defect measured using a periodontal probe by bone sounding at 6 and 12 months after treatment<br> 4. Reduction of the red-complex bacteria in microbiological samples from the treated implants measured using 4 sterile paper points after the removal of all supra-mucosal deposits with a cotton pellet at 3, 6 and 12 months after treatment. Paper points are introduced into the peri-implant pocket until slight resistance and remain in situ for 30 secs. They are then put in sterile tubes and sent to a commercial microbiological laboratory for analysis.<br>