Does a ThoracoLumbar Interfacial Plane (TLIP) Block With Liposomal Bupivacaine Provide Extended Post-operative Analgesia Following Spinal Surgery
Overview
- Phase
- Phase 2
- Intervention
- Liposomal bupivacaine
- Conditions
- Pain, Postoperative
- Sponsor
- The Cooper Health System
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Reduction in postoperative pain
- Last Updated
- 5 years ago
Overview
Brief Summary
The investigators are looking to recruit patients into a study demonstrating the effectiveness of a superficial nerve block involving the thoracolumbar interfascial plane (TLIP) in reducing postoperative pain in those undergoing spinal surgery
Detailed Description
Patients undergoing spine surgery with or without fusion experience a great deal of pain especially in the first 3 days after surgery. Spine surgeons are looking for ways to reduce the pain that you experience. Anesthesiologists have introduced a procedure, called a "TLIP block" to provide pain relief. The block involves injecting local anesthetic (numbing pain medication) in the lower back around the site of the surgery. This block has been used by other surgeons for other types of surgeries in the past and has been shown to work. To determine how effective the block is, the investigators are conducting this investigational study where pain severity in patients who receive one of 2 kinds of local anesthetic or placebo are compared
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients undergoing multilevel lumbar spine surgery, age 18-75
Exclusion Criteria
- •Opioid use disorder, previous spine surgery, non english-speaking patients, patients with anticipated communication disorders, patients with coagulopathy, prisoners, children, pregnant women, single level hemilaminectomy with or without discectomy
Arms & Interventions
Liposomal Bupivicaine
Administration of a combination of lioposomal bupivicane 20ml/266mg mixed with 20mL of 0.375% bupivicaine
Intervention: Liposomal bupivacaine
Bupivicane
Administration of 40 ml of 0.375% Bupivicaine with epinephrine 1:400,000
Intervention: Bupivacaine Injection
Placebo
Saline injection with 40mL preservative-free saline
Intervention: Placebo
Outcomes
Primary Outcomes
Reduction in postoperative pain
Time Frame: 24-48 hours
Using Visual Analog Scales on a scale of 0-10, where 0 is no pain and 10 is the worst pain
Total postoperative opioid requirements
Time Frame: 1-5 days
Using daily MME
Secondary Outcomes
- Length of Hospital Stay(1-5 days)
- Time to Ambulation(1-5 days)