Impact of Preemptive Intravenous Ibuprofen on Postoperative Edema and Trismus in the Third Molar Teeth

Not Applicable

• Conditions: Trismus; Edema
• Interventions: Drug: arveles; Drug: intrafen; Other: placebos

• Registration Number: NCT03170713
• Lead Sponsor: Erzincan University

Brief Summary

this study was planned to investigate the antiinflammatory activity of preemptive intravenous ibuprofen on inflammatory complications such as edema and trismus after third molar tooth surgery

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2017-05
• Study Start: 2017-05-15
• Study First Submitted: 2017-05-20
• Study First Submitted QC: 2017-05-26
• Last Update Submitted: 2017-05-26
• Study First Posted: 2017-05-31
• Last Update Posted: 2017-05-31
• Primary Completion: 2017-10-30
• Study Completion: 2017-11-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Elective 3. Molar tooth extraction
• Patients between the ages of 20-35
• Patients who are symptomatic
• 3. Molar tooth angular or horizontal settled patients

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Exclusion Criteria

• Patients who refuse to participate in the study
• Patients under 20 years old, over 35 years old
• Patients who are allergic to known non-steroidal anti-inflammatory drugs
• Pregnant patients
• Patients with severe hepatic insufficiency
• Patients with severe renal insufficiency

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
placebos	intrafen	Pre-operative 150 cc normal saline will be delivered in 30 minutes
arveles	arveles	800 mg ibuprofen and 50 mg arveles in 150 cc normal saline before operation will be given in 30 minutes.
arveles	intrafen	800 mg ibuprofen and 50 mg arveles in 150 cc normal saline before operation will be given in 30 minutes.
arveles	placebos	800 mg ibuprofen and 50 mg arveles in 150 cc normal saline before operation will be given in 30 minutes.
intrafen	arveles	intrafen 800 mg in 150 cc normal saline before operation will be given in 30 minutes.
intrafen	intrafen	intrafen 800 mg in 150 cc normal saline before operation will be given in 30 minutes.
intrafen	placebos	intrafen 800 mg in 150 cc normal saline before operation will be given in 30 minutes.
placebos	arveles	Pre-operative 150 cc normal saline will be delivered in 30 minutes

Primary Outcome Measures

Name	Time	Method
Edema size measured by tape measure method	6 month	the effect of preemptive intravenous ibuprofen on postoperative edema size

Secondary Outcome Measures

Name	Time	Method
Maximum mouth opening measured with vernier caliper	6 month	the effect of preemptive intravenous ibuprofen on postoperative trismus rate

Trial Locations

Locations (1)

Erzincan University; 🇹🇷 Erzincan, Turkey