NCT01055717已完成不适用
Bioavailability of Avenanthramide-Enriched Oats in Healthy Older Adults
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Levels of avenanthramides and their in vivo metabolites in blood, urine, and feces following the consumption of avenanthramide-enriched oats delivered in a baked muffin
研究概览
简要总结
This is a placebo-controlled, crossover study investigating the pharmacokinetic bioavailability of avenanthramides from avenanthramide-enriched oats and their in vivo metabolites in a cohort of healthy, older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and postmenopausal women
- •BMI 18.5-29.9 kg/m2
排除标准
- •Cigarette smoking and/or nicotine replacement use
- •Use of cholesterol-lowering medications
- •Use of blood pressure-lowering medications
- •Use of any stomach acid-lowering medications
- •Cardiovascular (heart) disease
- •Gastrointestinal disease
- •Kidney disease
- •Endocrine disease: including diabetes, untreated thyroid disease
- •Rheumatoid arthritis
- •Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- •Systolic blood pressure > 150 mm Hg and/or diastolic blood pressure > 95 mm Hg
- •Regular use of oral steroids
- •Regular daily intake of 2 or more alcoholic drinks
- •Illicit drug use
- •No fish oil supplements (including cod liver oil) for one month prior to study admission
- •No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
结局指标
主要结局
Levels of avenanthramides and their in vivo metabolites in blood, urine, and feces following the consumption of avenanthramide-enriched oats delivered in a baked muffin
时间窗: 24 hours
次要结局
未报告次要终点
研究者
研究点 (2)
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