Endoscopic Tri-Modal Imaging for the detection of early neoplasia in patients with Barrett's oesophagus in tertiary referral Centres: a randomised cross-over multicentre study

Completed

• Conditions: Barrett's oesophagus, autofluorescence imaging, narrow band imaging; Cancer; Early neoplasia detection

• Registration Number: ISRCTN68328077
• Lead Sponsor: Academic Medical Centre (AMC) (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05-30
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 84

Inclusion Criteria

1. Aged greater than 18 years
2. Prior diagnosis of BE defined as the presence of columnar lined epithelium in the tubular oesophagus with specialised intestinal metaplasia on histological investigation
3. Prior diagnosis of high-grade dysplasia or early cancer that was endoscopically inconspicuous according to the referring physician. Review of the pathology slides is not required for inclusion
4. A minimum Barrett's length of C greater than 2M greater than 2 or C less than 2M greater than 4 according to the Prague C&M classification of the endoscopic appearance of BE
5. Written informed consent

Exclusion Criteria

1. Presence of active erosive oesophagitis greater than grade A according to the Los Angles classification of erosive oesophagitis
2. Description of an endoscopically visible suspicious lesion in the Barrett's segment in the referring centre
3. Presence of conditions precluding histological sampling of the oesophagus (e.g. oesophageal varices, coagulation disorders, anticoagulant therapy)

Study & Design

• Study Type: Interventional
• Study Design: Not specified