Mechanisms of Visual Restoration After Occipital Stroke

Not yet recruiting

• Conditions: Cortical Blindness; Stroke Ischemic; Vision Loss Partial; Visual Fields Hemianopsia; Hemianopia; Hemianopia Homonymous; Occipital Lobe Infarct

• Registration Number: NCT07134777
• Lead Sponsor: University of Rochester

Brief Summary

This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system. Our goal is to improve understanding of the consequences of permanent visual cortex damage in humans, and to understand how visual training impacts the function of the residual visual system to restore perception.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-07-29
• Status Verified: 2025-08
• Study First Submitted QC: 2025-08-14
• Last Update Submitted: 2025-08-14
• Study First Posted: 2025-08-21
• Last Update Posted: 2025-08-21
• Study Start: 2025-08-31
• Primary Completion: 2029-08-01
• Study Completion: 2029-08-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterize visual response prior to visual training	Baseline, Visit 2, Optional visits 3-7	Visual responses of different brain areas spared by the patients stroke will be analyzed using a population receptive field (pRF) method.
Characterize how visual response properties in residual visual areas change following a period of visual training	Baseline, Visit 2, Optional visits 3-7	Characterize how visual response properties in residual visual areas change following a period of visual training. Visual responses of different brain areas will be analyzed using a population receptive field (pRF) method.
Identify visual areas of damage	Baseline, Visit 2, Optional visits 3-7	Use fMRI scans to identify areas of damage

Trial Locations

Locations (1)

University of Rochester; 🇺🇸 Rochester, New York, United States