A study of myocardial cell dysfunction in right ventricle in patients with chronic thromboembolic pulmonary hypertensio

Not Applicable

• Conditions: Chronic thromboembolic pulmonary hypertension: CTEPH

• Registration Number: JPRN-UMIN000024463
• Lead Sponsor: Graduate School of Medicine, Chiba University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-11-02
• Study Completion: 2020-01-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Not provided

Exclusion Criteria

Exclusion Criteria: 1.Clinically significant biochemical abnormality. 2.Clinical evidence of pre-existing neuropathy. 3.Use of investigational product or device within 30 days prior to dosing, or known requirement for any investigational agent prior to completion of all scheduled study assessments. 4.Known to be positive for human immunodeficiency virus (HIV). 5.Additional medical condition, serious intercurrent illness, or other extenuating circumstance that, in the opinion of the Investigator, may significantly interfere with study compliance, including all prescribed evaluations and follow-up activities, including past history of myocardial infarction, unstable angina, and poorly controlled diabetes mellitus. 6.Blood results (performed within 14 days from study registration) as outlined below: oCreatinine > 2.0 mg/dl oBUN > 30 mg/dl oALT >150 U oAST >150 U 7.Pregnant or lactating at screening, or planning to become pregnant (self or partner) at any time during study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of mitochondrial dysfunction in right ventricle myocardial cells by using biopsy samples extracted during pulmonary endarterectomy