The Relationship Between Sex Hormone Binding Globulin, Testosterone and Glycemic Control in Patients With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 主要终点
- sex hormone-binding globulin
研究概览
简要总结
Sex hormone-binding globulin(SHBG) is a surrogate marker of insulin resistance. This study aims at the characteristic and clinical significance of SHBG and testosterone in patients with type 2 diabetes(T2D).
详细描述
The investigators recorded clinical factors, biochemical criterion such as serum levels of glucose and lipids, HbA1c, SHBG, testosterone, insulin, EPO, C-peptide, glucagon, microalbuminuria, glycemic variation via CGM, carotid plaque, ECG and ultrasonic cardiogram in patients with T2D who visited in the Department of Endocrinology at the Nanjing First Hospital from January 2015 to Aprol 2018. The relationship between levels of SHBG, testosterone and glycemic variation/diabetic complications are analysed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •● Patients with T2D and the diagnostic criteria of T2D is according to the World Health Organization in 1999.
排除标准
- •Patients use systemic steroidal anti-inflammatory drugs.
- •Patients with an acute infection.
- •Patients with acute complication of diabetes.
结局指标
主要结局
sex hormone-binding globulin
时间窗: Day 1
the blood sex hormone-binding globulin level of patients
次要结局
- Testosterone(Day 1)
- EPO(Day 1)
- HbA1c(Day 1)
- MBG(Day 1-4)
- MAGE(Day 1-4)
- SD(Day 1-4)