Functional MRI of cognitive control in autism

Completed

Conditions: autism
10012562

Registration Number: NL-OMON35416

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 300

Inclusion Criteria

General inclusion criteria:
- 6-16 years ;Inclusion criteria for subjects with autism:
- DSM-IV diagnosis of autism, according to diagnostic interview (ADI-R);Inclusion criteria for controls:
- no DSM-IV diagnosis according to diagnostic interview (DISC)
- no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
- IQ>70

Exclusion Criteria

- history or presence of major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
- presence of metal objects in or around the body (pacemaker, dental braces)
- history or presence of neurological illness

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure in the fMRI studies will be MR signal. This signal<br /><br>represents the activation level (compared to a control condition) and is<br /><br>hypothesized to differ in fronto-striatal regions between children with autism<br /><br>and control children. A second, behavioral outcome measure is performance<br /><br>(reaction times and accuracy) on the cognitive controls tasks. The primary<br /><br>outcome measure for the DTI-scans will be anisotropy (representing the unequal<br /><br>regional diffusion of water), which is a measure of regional white matter<br /><br>regularity. Finally the primary outcome measure of the exploratory genetic<br /><br>studies will also be MR signal, which we hypothesize will differ in<br /><br>fronto-striatal regions between groups with different genetic profiles.</p><br>

Secondary Outcome Measures