Functional MRI of Cognitive Control in Autism
- Conditions
- Autism
- Registration Number
- NCT00463164
- Lead Sponsor
- UMC Utrecht
- Brief Summary
This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 90
- Aged 6 - 12 years at inclusion
Inclusion criteria for subjects with autism
- DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview
Inclusion criteria for controls
- No DSM-IV (APA, 1994) diagnosis, according to DISC interview
- No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
- IQ > 70
- Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
- Presence of metal objects in or around the body (pacemaker, dental braces)
- History of or present neurological disorder
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dept. of Child and Adolescent Psychiatry, UMC Utrecht
🇳🇱Utrecht, Netherlands