Personal protein digestion variability

Completed

• Conditions: opname van eiwitten; protein digestion

• Registration Number: NL-OMON51132
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

* Apparently healthy men and women;
* Age between 18 and 40 years;
* Body mass index (BMI) between 18.5 and 30 kg/m2 ;
* Having veins suitable for blood sampling via a catheter (judged by study
nurse/ medical doctor).

Exclusion Criteria

* Any metabolic, gastrointestinal, inflammatory or chronic disease (such as
diabetes, anaemia, hepatitis, cardiovascular disease),or having a condition or
disease that may lead to an impaired immune system
* History of gastrointestinal surgery or having (serious) gastrointestinal
complaints;
* History of liver dysfunction (cirrhosis, hepatitis) or liver surgery;
* Kidney dysfunction (self-reported);
* Any use of medication that may suppress the immune system, this will be
judged by the medical supervisor;
* Use of medication that may influence the study results, such as gastric acid
inhibitors, laxatives, stomach protectors and drugs that can affect intestinal
motility, this will be judged by the medical supervisor;
* Anaemia (Hb values <7.5 mmol/L for women and <8.5 mmol/L for men);
* Reported slimming, medically prescribed or other extreme diets;
* Not willing to give up blood donation during the study;
* Current smokers;
* Alcohol intake *4 glasses of alcoholic beverages per day;
* Pregnant, lactating or wishing to become pregnant in the period of the study
(self-reported);
* Abuse of hard drugs;
* Not having a general practitioner;
* Participation in another clinical trial at the same time;
* Being an employee of the department Food, Health & Consumer Research of
Wageningen Food & Biobased Research or the department of Nutrition and Health
of Wageningen University

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is AA uptake kinetics e.g. the appearance of free<br /><br>amino acids in blood samples collected before and after consumption. We will<br /><br>determine and quantify between, and within-subject variability. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>GI complaints via questionnaire</p><br>