Prevalence of fructose malabsorption in patients with gout.

Not Applicable

Completed

• Conditions: Gout; Intestinal fructose malabsorptionThe proposed investigation aims to identify the rates of fructose malabsorption in patients with gout. It is anticipated that this will then lead to further studies of dietary manipulation in patients with and without fructose malabsorption to determine whether dietary fructose restriction results in reduction in serum urate to a greater or lesser extent in each group.; Intestinal fructose malabsorption; The proposed investigation aims to identify the rates of fructose malabsorption in patients with gout. It is anticipated that this will then lead to further studies of dietary manipulation in patients with and without fructose malabsorption to determine whether dietary fructose restriction results in reduction in serum urate to a greater or lesser extent in each group.; Musculoskeletal - Other muscular and skeletal disorders; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12612000879864
• Lead Sponsor: niversity of Otago, Christchurch

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-08-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Male or female aged >/=18 years

2. Patients fulfil the ACR preliminary classification criteria for gout (Wallace et al. 1977)

3. Subjects are willing and able to participate in the study and from whom written informed consent has been obtained.

Exclusion Criteria

1. Known inflammatory bowel disease or irritable bowel syndrome

2. Receiving diuretic or antibiotic therapy

3. Presence of chronic infection or other severe concomitant medical illness or psychiatric disease.

4. Patients with active, concomitant malignancies.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine whether patients with gout have lower rates of fructose malabsorption compared to the general population.<br>This will be determined using the fructose breath test using a Quintron microlyser DP[The breath test will be undertaken once only.]

Secondary Outcome Measures

Name	Time	Method
To determine the effect of fructose malabsorption (assessed by breath test) on serum urate[Fructose breath test performed over 180minutes and serum urate measured at time 0, 15, 30, 60, 90, 120, 180 and 240 mins]