Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

Completed

• Conditions: Colloid Osmotic Pressure

• Registration Number: NCT01044979
• Lead Sponsor: Haukeland University Hospital

Brief Summary

The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Detailed Description

Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2009-12-17
• Study First Submitted QC: 2010-01-07
• Study First Posted: 2010-01-08
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Status Verified: 2014-07
• Last Update Submitted: 2014-07-03
• Last Update Posted: 2014-07-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adults over 18 years

Exclusion Criteria

• Ongoing illness
• Medication

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Colloid osmotic pressure	60 and 90 minuttes after implanting wicks

Trial Locations

Locations (1)

Haukeland University Hospital; 🇳🇴 Bergen, Norway