Multiomics in systemic inflammation driven brain aging in humans
- Conditions
- postoperative cerebral dysfunctionPostoperative cognitive decline (POCD)100146231000318410002363
- Registration Number
- NL-OMON56946
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 0
Planned for elective thoraco-abdominal aortic aneurysm repair that also have an
ELD as part of their routine clinical care at Radboudumc
- Disease states associated with a state of neuroinflammation: brain or spinal
surgery within the last 6 months, meningitis or brain infection within the last
6 months, presence of a CSF catheter or shunt, presence of known brain tumor,
brain injury (e.g., stroke, or subarachnoid hemorrhage) within the last 12
months, moderate-severe brain trauma in previous medical history, chronic
active alcoholism or substance use.
- Pre-existing dementia or neurodegenerative disease
- Cognitive impairment interfering with the ability to understand informational
study material.
- Chronic (>2 weeks) use of immunosuppressive agents (see table 3.3.A, below)
- Concomitant diseases resulting in severe immunosuppression (e.g., HIV,
hematological malignancies)
- Patients that do not speak Dutch or analphabetic patients.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
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