Transcranial Alternating Current Stimulation (tACS) as a novel treatment option: a proof of concept study in Adult Classic Galactosemia

Completed

• Conditions: classic galactosemia; GALT deficiency; 10027424; 10028037

• Registration Number: NL-OMON49032
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Patient group:
The patient may participate in the study, if they meet these criteria:
- Adult age: 18 years or older
- GALT enzyme activity below 10% and/or GALT gene severe disease causing
mutations
- Motor sequencing and/or word productions problems
- Documented motor and language impairments
- Capable of giving informed consent
- The participants are screened pre and post intervention using standardized
tests. Participants with abnormal scores in cognitive and/or motor domains are
eligible.

Control group:
Healthy controls are included if they meet the following criteria:
- Adult age: 18 years or older
- No motor, language and/or cognitive impairments
- Capable of giving informed consent

Exclusion Criteria

- Motor and language problems due to other causes
- Eczema
- Psoriasis
- Epilepsy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Language/speech task<br /><br>Reaction times and accuracy will be compared pre, during and post stimulation<br /><br>within the CG group and between groups. To validate a relation of theta and<br /><br>beta oscillation on language problems, we will compare the EEG theta and beta<br /><br>power spectrum of CG and healthy controls during the active language task and<br /><br>in resting state data. To investigate the relation between tACS and brain<br /><br>oscillation we will compare theta and beta power in pre and post stimulation<br /><br>EEG. To validate a relation of speech behavior and tACS we will investigate the<br /><br>relation of theta power pre-post difference and behavior pre-post difference in<br /><br>both groups of participants.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>