Transcranial alternating current stimulation for apathy in Huntington's disease

Monash University0 sites44 target enrollmentJune 19, 2019

Overview

No summary available.

Registry

who.int

Start Date

June 19, 2019

End Date

August 2, 2021

Last Updated

3 years ago

Study Type

Interventional

Sex

All

Sponsor

•Individuals with genetically confirmed prodromal or early stage HD, as well as individuals without HD matched for age, gender and education will be sought as participants.
•\-Participants with prodromal HD will need to be within approximately 12 years of expected motor onset or have a disease burden score” (DBS) of at least 280, indices calculated using the prospective participant’s current age and number of CAG repeats on the affected allele.
•\-Participants with early stage manifest HD will need to have a total functional capacity (TFC) score greater than, or equal to 10 . The TFC is used to assess how much assistance a person with HD requires to perform tasks in five functional domains that decline with disease progression (i.e., occupation, finances, domestic chores, activities of daily living, and care level).

•\- Use of anticonvulsant medications or regular treatment with benzodiazepines (versus limited as\-needed use, with none consumed within the 48 hours prior to an experimental session).
•\-Commencement or significant dosage alteration of other psychotropic medications (i.e., anti\-depressants, anti\-psychotics) during the four weeks prior to an experimental session.
•\-Choreiform movements that preclude tACS or EEG data collection.
•\-A current episode of psychiatric illness, or a current substance use or alcohol use disorder, initially assessed via the recruitment screen, and then as assessed and defined by the Mini International Neuropsychiatric Interview (MINI) 7\.0\.2\.
•\-Any history of significant head injury or traumatic brain injury, as defined by a loss of consciousness greater than 30 minutes or requiring a hospital admission.
•\-Unstable medical illness.
•\-Pregnancy or breastfeeding.
•\-An uncorrected hearing or visual impairment (including difficulty with colour perception).
•\-Significant difficulties with understanding or communicating in English.
•\-Metallic implants within the head, a pacemaker, cochlear implant, medication pump or other electronic device within the body.