Transcranial alternating current stimulation for apathy in Huntington's disease

Monash University0 个研究点目标入组 44 人开始时间: 2019年6月19日最近更新: 2022年9月5日

适应症

试验速览

暂无简介。

•Individuals with genetically confirmed prodromal or early stage HD, as well as individuals without HD matched for age, gender and education will be sought as participants.
•-Participants with prodromal HD will need to be within approximately 12 years of expected motor onset or have a disease burden score” (DBS) of at least 280, indices calculated using the prospective participant’s current age and number of CAG repeats on the affected allele.
•-Participants with early stage manifest HD will need to have a total functional capacity (TFC) score greater than, or equal to 10 . The TFC is used to assess how much assistance a person with HD requires to perform tasks in five functional domains that decline with disease progression (i.e., occupation, finances, domestic chores, activities of daily living, and care level).

•- Use of anticonvulsant medications or regular treatment with benzodiazepines (versus limited as-needed use, with none consumed within the 48 hours prior to an experimental session).
•-Commencement or significant dosage alteration of other psychotropic medications (i.e., anti-depressants, anti-psychotics) during the four weeks prior to an experimental session.
•-Choreiform movements that preclude tACS or EEG data collection.
•-A current episode of psychiatric illness, or a current substance use or alcohol use disorder, initially assessed via the recruitment screen, and then as assessed and defined by the Mini International Neuropsychiatric Interview (MINI) 7.0.2.
•-Any history of significant head injury or traumatic brain injury, as defined by a loss of consciousness greater than 30 minutes or requiring a hospital admission.
•-Unstable medical illness.
•-Pregnancy or breastfeeding.
•-An uncorrected hearing or visual impairment (including difficulty with colour perception).
•-Significant difficulties with understanding or communicating in English.
•-Metallic implants within the head, a pacemaker, cochlear implant, medication pump or other electronic device within the body.

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