Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD)
Completed
- Conditions
- F90.0Disturbance of activity and attention
- Registration Number
- DRKS00010907
- Lead Sponsor
- Department of Psychology, European Medical SchoolCarl von Ossietzky Universität
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
•Age: 18-60
•Emmetropia
•Right-handedness
•German speaking
•ADHD diagnosis based on DSM-V
•Retrospektive perserverence of ADHD symptomatology into adulthood (Wender-Utah-Rating Scale: Retz-Junginger, Retz et al. 2002)
•informed consent
Exclusion Criteria
•Magnetizable metal near brain/skull
•Cochlea implants
•Implanted neurostimulator
•Epilepsiy (within previous medical history or family)
•(comorbide) neurologic conditions
•Severe affective disorders/schizophrenia/substance addiciton/autism
•Dermatosis
•Pregnancy
•Medication had to be discontinued at least 3 days prior to the day of measurement
•No other psychopharmacological medication
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method P300 amplitude was defined as the maximum value of the averaged ERP waveform in µV at Pz electrode per block and patient. P300 parameters were derived from pre and post block trials respectively. Indiviual change pre-to-post was then compared between the experimental groups. (2 x 2 design)
- Secondary Outcome Measures
Name Time Method Response time in ms, defined as time between presentation and button press (instructed for oddball X stimuli), averaged over block and patient. 2 types of errors measured in absolute number: Miss when button was not pressed in time window between 200 and 1000ms after X presentation, False Alarm when button was pressed in response to O stimulus, averaged across block and patient. Group were then compared using individual differences between the block averages. (2 x 3 design)