Interval Training in Bipolar Disorder

Not Applicable

Completed

• Conditions: Bipolar Disorder
• Interventions: Behavioral: Interval Training; Behavioral: Control; Behavioral: Continuous Training

• Registration Number: NCT02498730
• Lead Sponsor: Universidade Federal do Rio de Janeiro

Brief Summary

Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Detailed Description

Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Study Timeline

• Study First Submitted: 2015-07-11
• Study First Submitted QC: 2015-07-14
• Study First Posted: 2015-07-15
• Study Start: 2015-08
• Primary Completion: 2017-07
• Study Completion: 2017-07
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-27
• Last Update Posted: 2022-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Bipolar Criteria (DSM-IV),
• sedentary lifestyle

Exclusion Criteria

• 60 and over,
• Cardiovascular Disease,
• Panic disorder,
• Metabolic syndrome Diagnosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Interval Training	Interval Training	6 stimulous (30 s) at 100% VO2Max/ 1 min 30 s to rest, 19 minutes (total exercise), 3 times/ week, 12 weeks
Interval Training	Continuous Training	6 stimulous (30 s) at 100% VO2Max/ 1 min 30 s to rest, 19 minutes (total exercise), 3 times/ week, 12 weeks
Control	Control	Only Dependent Variables Measures
Continuous Training	Continuous Training	Running at 60% VO2Max, 25 minutes (total exercise), 3 times/week, 12 weeks
Continuous Training	Interval Training	Running at 60% VO2Max, 25 minutes (total exercise), 3 times/week, 12 weeks

Primary Outcome Measures

Name	Time	Method
Symptom Scales (Hamilton and Young)	0 week, 6 week, 12 week	Variable Measured to reduction of symptoms

Secondary Outcome Measures

Name	Time	Method
Cortical Changes (EEG) - Loreta	0 week, 6 week, 12 week	Measured to evaluate changes due to training
Cognitive Function	0 week, 6 week, 12 week	Executive Function, Time Reaction, Atention, and Memory
VO2Max	0 week, 6 week, 12 week	Variable Measured to assess cardiovascular improvement

Trial Locations

Locations (1)

Institute of Psychiatry (IPUB); 🇧🇷 Rio de Janeiro, Brazil