Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait

Not Applicable

Terminated

• Conditions: Parkinson Disease

• Registration Number: NCT02704195
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease

Detailed Description

Unilateral modulation of subthalamic stimulation and its impact on freezing of gait in Parkinson's disease will be studied.

In a cross-over, doubleblind, randomized study, a 30% reduction of stimulation intensity of the less impacted side will be compared with chronic treatment with regard to frequency and duration of freezing of gait episodes.

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2016-03-04
• Study First Submitted QC: 2016-03-04
• Study First Posted: 2016-03-09
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-20
• Last Update Posted: 2016-09-21

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Patients affiliated to social security Patient with idiopathic parkinson's disease, with deep brain stimulation since at least one year Freezing of gait Able to give inform consent

Exclusion Criteria

Patient under guardianship, legal guardianship Psychosis Severe depression Severe cognitive troubles (Mattis < 130) Other neurologic or medical pathology interfering with gait

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
improvement of Freezing of gait	1 month after new stimulation parameters	the improvement will be measure with a composite score of items 12 + 13 on UPDRS II and items 10+11 on UPDRS III,

Trial Locations

Locations (1)

CHU Grenoble; 🇫🇷 Grenoble, France