Subthalamic Nucleus, Akinesia and Parkinson's Disease

Not Applicable

Recruiting

• Conditions: Parkinson's Disease

• Registration Number: NCT01682668
• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Brief Summary

This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN stimulation improves motor signs in PD patients .

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-07-19
• Study First Submitted QC: 2012-09-07
• Study First Posted: 2012-09-11
• Study Start: 2013-02
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-25
• Last Update Posted: 2024-11-27
• Primary Completion: 2025-05
• Study Completion: 2025-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Firing rate of the subthalamic neurons	During surgery for bilateral STN stimulation	Changes in the neuronal activity of the STN before, during and after the execution of an arm movement

Secondary Outcome Measures

Name	Time	Method
Evoked related potentials of the STN	3-5 days after surgery for bilateral STN stimulation	Local-field potentials recordings with DBS electrodes when performing the execution of an arm movement or gait initiation
Biomechanical parameters of gait initiation	6 months	Gait initiation parameters by using a forceplate and EMG recordings

Trial Locations

Locations (2)

CIC-GHPS; 🇫🇷 Paris, France

Groupe Hospitalier Pitie-Salpêtrière; 🇫🇷 Paris, France