Correlation Between Urine UACR and Postoperative Neurocognitive Disorder in Elderly Patients With Non-cardiac Surgery

• Conditions: Postoperative Cognitive Dysfunction; Delirium

• Registration Number: NCT03860714
• Lead Sponsor: Han Yuan

Brief Summary

This study intends to evaluate the relationship between urinary albumin/creatinine ratio and postoperative neurocognitive impairment in elderly non-cardiac surgery patients. The results of the study are to identify risk factors, screen high-risk populations to improve clinical evidence, early detection and early treatment.And reducing the burden of PNCD on patients and their families, hospitals and public resources.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-01
• Status Verified: 2019-02
• Study First Submitted: 2019-02-22
• Study First Submitted QC: 2019-02-27
• Last Update Submitted: 2019-02-27
• Study First Posted: 2019-03-04
• Last Update Posted: 2019-03-04
• Primary Completion: 2019-12-30
• Study Completion: 2020-05-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Non-cardiac surgery patients;

  • Age is greater than or equal to 60 years old; ③Han Nationality, mother tongue is chinese;

    ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

    ⑤The people signed informed consent.

Exclusion Criteria

• The diagnosis of preoperative delirium；

  • The diagnosis Unstable hypertension（Such as：pheochromocytoma or aortic dissection）； ③Severe chronic obstructive pulmonary disease or congestive heart failure； ④Severe liver and kidney dysfunction;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Confusion Assessment Method（CAM)	afternoon of the 3st day after surgery	Confusion Assessment Method to measure delirium

Secondary Outcome Measures

Name	Time	Method
Mini-Mental score examination (MMSE) and Neuropsychological tests	one month after surgery	Mini-Mental score examination (MMSE) and Neuropsychological tests to measure cognitive function, including the Trail
serum branched chain amino acid content	1 day before surgery(baseline)	Record preoperative serum branched chain amino acid content
Quality of Recovery Score - 40 (QoR-40)	1 day after surgery	Quality of recovery will be evaluated by Quality of Recovery 40 (QoR40),which assesses five dimensions of recovery (physical comfort,emotional state, physical independence , physiological support and pain ). Each item is rated on a five-point Likert scale: none of the time, some of the time, usually, most of the time, and all the time. The total score on the QoR40 ranges from 40 (poorest quality of recovery) to 200 (best quality of recovery).
serum vitamin B12 levels	1 day before surgery(baseline)	Record preoperative serum vitamin B12 levels
serum homocysteine content	1 day before surgery(baseline)	Record preoperative serum homocysteine content
Numerical Rating Scale（NRS）	afternoon of the 3st day after surgery	Evaluate the severity using numerical rating scale（NRS）, where zero mean no pain and 10 the worst imaginable pain.
Mini-Mental score examination (MMSE)	1 day before surgery(baseline)	Mini-Mental score examination \[MMSE\] used for screening of dementia
serum folic acid levels	1 day before surgery(baseline)	Record preoperative serum folic acid levels

Trial Locations

Locations (1)

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University; 🇨🇳 Xuzhou, Jiangsu, China