Avastin in the prevention of postoperative scarring after glaucoma filtration surgery.
Phase 1
Completed
- Conditions
- Glaucoma, uncontrolled intraocular eye pressure, trabeculectomy, postoperative intervention, subconjunctival delievery.Eye - Diseases / disorders of the eye
- Registration Number
- ACTRN12607000318482
- Lead Sponsor
- Monash Universtity
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Patients within 4 weeks of their first trabeculectomy who are deemed on clinical grounds to require the standard antiscarring treatment (5 FU).
Exclusion Criteria
Active or recent bleb leak, known hypersensitivity to 5 FU, only eye, active bleb inflammation, inability to complete the informed consent, uncontrolled systemic condition within the previous month.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of participants with an intraocular eye pressure >8mmHg and <21mmHg with no topical therapy[At 3 months post treatment]
- Secondary Outcome Measures
Name Time Method Bleb vascularity and morphology (graded by a masked observer according to Moorfields bleb grading scheme).[At 1, 6 and 12 week follow up appointment time points.]