NCT07184814招募中不适用
Clinical Features and Prognosis of Takayasu's Arteritis With Pulmonary Arteries Involvement
China-Japan Friendship Hospital1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2016年1月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- All-cause death
研究概览
简要总结
The purpose of this study is to identify the clinical features, management pattern and long-term outcomes of patients with pulmonary arteries involvement in Takayasu's arteritis (TAK-PAI).
详细描述
The present study intends to conduct a prospective analysis of the clinical data in TAK patients in order to:
- describe the clinical characteristics and current status of multimodal treatment in patients with TAK-PAI, thereby enhancing the understanding of TAK-PAI;
- to investigate the risk factors for mortality in patients with TAK-PAI, so as to promote early intervention and reduce mortality.
- explore factors associated with pulmonary hypertention (PH) in patients with TAK-PAI, so as to facilitate the early identification of patients who may develop PH.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized between Jan 1, 2016 and Dec 31, 2026
- •Diagnosed with TAK according to the modified Ishikawa criteria and/or 1990 American College of Rheumatology criteria and/or 2022 ACR/EULAR criteria
- •Diagnosed with pulmonary artery involvement using computed tomography pulmonary angiography or transcatheter pulmonary angiography
- •Patients without aortic or primary branch involvement who nonetheless exhibited both clinical features and computed tomography-confirmed evidence of pulmonary artery involvement (PAI), after exclusion of other diseases causing pulmonary artery stenosis or occlusion
排除标准
- •Patients with PAI caused by non-TAK diseases such as other types of vasculitis, fibrosing mediastinitis, pulmonary artery sarcoma, pulmonary sarcoidosis or chronic thromboembolic pulmonary hypertension
结局指标
主要结局
All-cause death
时间窗: At 3 months, 6 months, and annually thereafter following enrollment, until December 31, 2026.
次要结局
- Six-minute walk distance(At 3 months, 6 months, and annually thereafter following enrollment, until December 31, 2026)
- WHO functional class(At 3 months, 6 months, and annually thereafter following enrollment, until December 31, 2026.)
- N-terminal pro-brain natriuretic peptide level(At 3 months, 6 months, and annually thereafter following enrollment, until December 31, 2026)
研究者
Wanmu Xie
Director, Department of Integrative Pulmonary Medicine
China-Japan Friendship Hospital
研究点 (1)
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