Study of the Etiology, Clinical Picture, Complications and Outcomes of Necrotizing Pancreatitis in Children.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- the frequency of occurrence of various etiologic causes of necrotizing pancreatitis in children
研究概览
简要总结
The aim of this research is to study the etiology, the clinical picture, the management, the complications and the outcomes of necrotic pancreatitis in children.
Currently, there is a significant number of errors in the early diagnosis of AP in children associated with the complexity of differential diagnosis, which leads to the untimely verification of the correct diagnosis and, consequently, to incorrect treatment tactics, which could be accompanied by an increase in the severe forms of the disease and an increase in mortality.
详细描述
Acute pancreatitis (AP) is an acute inflammatory disease of the exocrine pancreas. Clinical manifestations vary from mild abdominal discomfort to metabolic disorders, sepsis, fluid sequestration, multiple organ failure and death. According to the international data, the annual incidence of AP in children is 3-13 cases per 100,000 people, but in recent years, there has been an increase in the incidence of this pathology. Necrotic pancreatitis in children accounts for up to 25-30% of the cases of all forms of AP. Despite the successes achieved in the diagnosis and treatment of AP, the mortality rate for this pathology is up to 5%, according to various authors. In addition, given the varying degrees of the prevalence of the destructive process in the pancreas and the parapancreatic tissue, the choice of surgical treatment still remains a subject of discussion. The treatment of moderately severe (MSAP) and severe (SAP) necrotic pancreatitis is a complex task due to the variety of causes of the disease, the incompletely understood pathogenesis and the uncertainty in predicting the results.
Paralytic ileus with the development of intestinal failure is the main pathogenetic factor in the development of a septic condition in AP, but there is tendency of insufficient attention being paid to this fact in pediatric practice, which determines the lack of a unified approach to the treatment of intestinal failure syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consent of the patient or legal representative
- •Age from 0-18 years
- •Moderate severe (MSAP) or severe acute pancreatitis (SAP) according to Atlanta criteria revisited in 2012
- •Acute Pancreatitis was established in the presence of at least two of three criteria according to the classification developed by the INSPPIRE group (International Study Group of Pediatric Pancreatitis: In Search for a Cure): abdominal pain corresponding to the diagnostic hypothesis; an increase in amylase and / or lipase in the blood serum by ≥3 times; imaging findings characteristic of AP: abdominal ultrasound and/or contrast-enhanced CT.
排除标准
- •mild acute pancreatitis
- •chronic pancreatitis
- •no consent from patient or legal representative
结局指标
主要结局
the frequency of occurrence of various etiologic causes of necrotizing pancreatitis in children
时间窗: From enrollment to the end of treatment (2 month)
based on the study, the most common causes of necrotizing pancreatitis in children will be identified
次要结局
- The duration from the onset of the disease to the start of the treatment(from the onset of the disease to the end of treatment (up to 20 weeks))
- The duration of hospital stay(from admission to hospital until the end of treatment (up to 8 weeks))
- The length of ICU stay(During ICU stay (up to 60 days))
- The effect of comorbidities on the severity of the disease(from admission to hospital until the end of treatment (up to 8 weeks))
- Paralytic ileus(from admission to hospital until the end of treatment (up to 8 weeks))
- Mortality(from admission to hospital until the end of treatment (up to 20 weeks))
- Enzymatic parapancreatitis(from admission to hospital until the end of treatment (up to 10 weeks))
- Intestinal failure(from admission to hospital until the end of treatment (up to 8 weeks))
- Purulent-necrotic parapancreatitis(from admission to hospital until the end of treatment (up to 20 weeks))
- Biliary obstruction(from admission to hospital until the end of treatment (up to 20 weeks))
- Surgical interventions(from admission to hospital until the end of treatment (up to 20 weeks))