Etiology, Clinical Manifestations and Risk Factors for Community-acquired Pneumonia in Patients Admitted to Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Proportion of patients who are stable at Day 3, 7 and 14
研究概览
简要总结
This is a descriptive clinical research aiming:
- To describe the clinical spectrum and clinical characteristics of community acquired pneumonia (CAP) in patients admitted to hospital
- To identify the etiology of CAP and the antibiotic sensitivity of the isolated organisms
- To identify the risk factors that influence the severity of CAP
详细描述
In Vietnam, the range and relative contribution of organisms causing CAP remain unclear, largely because diagnostic tools are limited and clinical research uncommon. An improved understanding of the risk factors, etiology and clinical outcomes of CAP in Vietnam would contribute to improved approaches to patient diagnosis and clinical management. This will be achieved by following the clinical and laboratory progress and treatment outcomes of in-patients diagnosed with CAP from admission to discharge. Comparative analyses will be between subgroups including survivor and non-survivor, severe CAP and non-severe CAP, known etiology and unknown etiology, SIRS, sepsis, severe sepsis and shock septic.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients > or = 18 years of age
- •Patient meets the criteria of pneumonia (below), established within 36h of hospitalization
- •Patient is not hospitalized or residing in a long-term-care facility within 14 days before the onset of symptoms
- •Patient has not been at a referral hospital for >2 days before admission to the study hospital
- •Informed consent to participate in the study is provided
排除标准
- •Severe immunosuppression as judged by the enrolling physician (e.g. HIV, leukemia, lymphoma, chemotherapy for solid tumors, long-term corticosteroid use or other immunosuppressive drugs)
- •Known active tuberculosis or current treatment for tuberculosis
结局指标
主要结局
Proportion of patients who are stable at Day 3, 7 and 14
时间窗: up to 14 days
• Criteria for clinical stability * Temperature \< or = 37.8oC * Heart rate \< or = 100 beats/min * Respiratory rate \< or = 24 breaths/min * Systolic blood pressure \> or = 90 mm Hg * Arterial oxygen saturation \> or = 90% or pO2 \> or = 60 mm Hg on room air * Ability to maintain oral intake * Normal mental status
次要结局
- Need for mechanical ventilation(participants will be followed for the duration of hospital stay, an expected average of 2 weeks)
- Length of ventilation time(participants will be followed for the duration of hospital stay, an expected average of 2 weeks)
- Day 14 mortality(14 days)
- Length of stay (days)(participants will be followed for the duration of hospital stay, an expected average of 2 weeks)