Comprehensive DNA Methylation Profiling in Crohn's Disease

• Conditions: Crohn Disease; Methylation; Illumina Human Methylation 850k BeadChip

• Registration Number: NCT03272152
• Lead Sponsor: Jinling Hospital, China

Brief Summary

Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's disease was performed. Genome-wide DNA methylation was determined using the Illumina HumanMethylation 850k BeadChip.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Status Verified: 2017-08
• Study First Submitted: 2017-08-31
• Study First Submitted QC: 2017-08-31
• Last Update Submitted: 2017-08-31
• Study First Posted: 2017-09-05
• Last Update Posted: 2017-09-05
• Primary Completion: 2017-09-30
• Study Completion: 2017-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 14

Inclusion Criteria

• Active Crohn's disease(CDAI score≥ 150)

Exclusion Criteria

• No ileal lesions
• Under treatment of immunomodulators, biologic agents or steroids

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intestinal inflammation under colonoscopy	Jan 2017 to Sep 2017	Intestinal ulcer or enteritisis observed under colonoscopy

Secondary Outcome Measures

Name	Time	Method
CDAI	Jan 2017 to Sep 2017	Crohns Disease Activity Index is measured.

Trial Locations

Locations (1)

Jinling Hospital; 🇨🇳 Nanjing, Jiangsu, China