Time course of hypothalamic-pituitary adrenal alterations in response to critical illness

Completed

• Conditions: Critical illness; Not Applicable

• Registration Number: ISRCTN98806770
• Lead Sponsor: KU Leuven

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30215187

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-30
• Study Completion: 2017-07-31
• Last Update Posted: 4 December 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 562

Inclusion Criteria

For patients:
1. Critically ill patients admitted for =7 days to one of the five ICUs from two departments (medical and surgical) in the University Hospitals Leuven
2. Age =18 years

For healthy volunteers:
1. Age-, gender- and BMI-matched to the included patients

Exclusion Criteria

For patients:
1. Predisposing factors of adrenal insufficiency:
1.1. Cerebral disease with intracranial hypertension threatening the neuroendocrine system
1.2. Pituitary disorders including (pan)hypopituitarism
1.3. Known adrenal disease (Cushing's syndrome or Addison's disease)
1.4. Treatment with glucocorticoids, other steroids or anti-steroid chemotherapy within the last 3 months
1.5. Use of etomidate within the last 72 hours
1.6. Other drugs predisposing to adrenal insufficiency: azoles, phenytoin, rifampicin, glitazones, imipramin, phenothiazine, phenobarbital
2. No arterial line in place
3. Ethical restrictions:
3.1. Moribund
3.2. Declined participation

For healthy volunteers:
1. Recent history of treatment with HPA-axis interfering drugs

Study & Design

• Study Type: Observational
• Study Design: Not specified