Investigating the effects of steroids given in pregnancy on infant stress responses

Not Applicable

• Conditions: Effects of antenatal corticosteroids on infant stress responses; Pregnancy and Childbirth

• Registration Number: ISRCTN49188855
• Lead Sponsor: niversity of Edinburgh

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-07-20
• Last Update Posted: 4 December 2023
• Study Completion: 2025-05-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 543

Inclusion Criteria

1. Women with a twin pregnancy with a planned caesarean birth scheduled between 35+0 and 38+6 weeks gestation who are enrolled in STOPPIT-3 (ISRCTN59959611)
2. Women aged 16 years or older and able to provide electronic or written consent

Exclusion Criteria

1. Women taking prescribed corticosteroid medication (orally, injected, inhaled or topical) within the last 3 months.
2. Women with planned vaginal birth.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Measurement of endogenous glucocorticoids, dexamethasone and its metabolites in maternal and cord blood and amniotic fluid in samples collected at birth.<br> 2. Measurement of glucocorticoid receptor in cord blood leukocytes collected at birth.<br> 3. Measurement of placental genes regulating glucocorticoids in placenta samples collected at birth.<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Salivary cortisol pre and post heel-prick at 5 days<br> 2. Hair cortisol at 5 days<br>