ltradian rhythms of cortisol after cardiac surgery

Not Applicable

Completed

• Conditions: Coronary artery disease / surgery / endocrinology; Surgery; Mechanical complication of coronary artery bypass and valve grafts

• Registration Number: ISRCTN22146594
• Lead Sponsor: niversity of Bristol (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03-05
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients having isolated CABG surgery must fulfil all the following criteria:
1. Patient having first time, elective CABG
2. Aged 18 - 80yrs
3. Operation to be carried out using median sternotomy
4. Written informed consent

Exclusion Criteria

Participant may not enter the study if any of the following apply:
1. Emergency operation
2. Previous sternotomy
3. Myocardial Infarction within the last month
4. Concomitant procedure with CABG
5. Left ventricular ejection fraction <30%
6. Operation to be carried out by other incision than median sternotomy (e.g. left thoracotomy)
7. Contraindication to ONCABG or OPCABG (eg. calcified aorta, intramuscular LAD, calcified coronaries, small target vessels)
8. Use of exogenous corticosteroids (including inhalers)
9. Past history of adrenal / pitiutary disease
10. Other major co-morbidities

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pattern (pulsatility) of cortisol secretion during the peri-operative period, measured using an automated electrochemoluminescent immunoassay (ECLIA)

Secondary Outcome Measures

Name	Time	Method
evels of ACTH and CBG measured at three points - anaesthetic induction, end of operation and at 24 hours post surgery