COMPARISON OF IN-LINE NEBULISATION WITHDEXMEDETOMIDINE VERSUS 2% XYLOCARD PRIOR TOEXTUBATION ON EXTUBATION RESPONSE IN PATIENTSUNDERGOING SURGERY UNDER GENERALANAESTHESIA- A RANDOMIZED DOUBLE BLINDCLINICAL TRIAL.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To assess and compare cough response in different groups during extubation.
研究概览
简要总结
This study is a randomised double blinded controlled study sone to assess to compare the effects of in-line nebulisation with dexmedetomidine vs 2% lidocaine prior to extubation on extubation response in patients undergoing surgery under general anaesthesia. The primary objective is to assess and compare cough response in different groups during extubation and the secondary outcomes are a) To assess and compare the hemodynamic changes during extubation, b) To assess emergence agitation c) To assess any complications, post extubation like stridor due to laryngospasm or any other cause, vomiting, wheeze, desaturation, pulmonary edema. d) Duration of recovery - the time between the point where sevoflurane is cut off and the point where extubation is done.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Written and valid consent ASA I and II Age 18 to 60 years Patients undergoing surgery under General Anaesthesia Duration less than 3 hours.
排除标准
- •Patient refusal Chronic smokers more than 20 pack years Patients with compromised cardiopulmonary respiratory status requiring special anaesthetic plan Head and neck surgery Any known allergy to the study drugs.
结局指标
主要结局
To assess and compare cough response in different groups during extubation.
时间窗: T0 | Point at which sevoflurane is cut off | T1 | Point where reversal agent is given | T2 | 2 mins after administration of reversal | TE | Point of extubation | T3 | 2 mins after extubation | T4 | 5 mins after extubation | T5 | 10 mins after extubation
次要结局
- To assess & compare the hemodynamic changes during extubation(Point at which sevoflurane is cut off)
- To assess emergence agitation(Point at which sevoflurane is cut off)
- To assess any complications, post extubation like stridor due to laryngospasm or any other cause, vomiting, wheeze, desaturation, pulmonary edema(Point at which sevoflurane is cut off)
- Duration of recovery - the time between the point where sevoflurane is cut off & the point where extubation is done(Point at which sevoflurane is cut off)