A Comparison of nebulisation with dexmedetomidine and nebulisation with 4% lignocaine to prevent response during intubatio
Phase 2
Not yet recruiting
- Conditions
- Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
- Registration Number
- CTRI/2023/03/050403
- Lead Sponsor
- Rajarajeswari medical college and hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA I and II patients of either sex.
2.Patients aged between 18 to 50 years.
3. Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation
Exclusion Criteria
1.History of allergy to study drug.
2.Renal and hepatic dysfunction.
3.Cerebrovascular disease, bronchial asthma, ischemic heart disease, seizure disorders.
4.Patients on drugs like antidepressants, antipsychotics, anxiolytics or anticonvulsants.
5.Patients with difficult airway.
6.Patients in whom Cormack and Lehane grade are 3 or 4, duration of laryngoscopy >30 seconds, unexpected difficulty in ventilation or intubation
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the efficacy of nebulised dexmedetomidine and nebulised lignocaine in attenuation of hemodynamic response to laryngoscopy and intubation in terms of Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP)Timepoint: 0,1,3,5,10 minutes
- Secondary Outcome Measures
Name Time Method side effects if anyTimepoint: 0,1,3,5,10 minutes