Effect of aerobic training and vitamin D supplementation on liver Fat, liver enzymes and lipid profile

Phase 1

Conditions: on-alcoholic fatty liver disease.
Fatty (change of) liver, not elsewhere classified
K76.0

Registration Number: IRCT20190423043359N1

Lead Sponsor: Razi University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 40

Inclusion Criteria

Ultrasound (US) confirmation of being in second or third grade of NAFLD and certified by an internist
25-OHD serum levels between 10 and 20 ng/ml
Being in second or third grade of NAFLD
Not having a specific diet and regular exercise program in the past year

Exclusion Criteria

Significant consumption of alcohol more than 20 gr per day
Presence of other liver diseases (B and C hepatitis)
Other disorders such as autoimmune hepatitis, joint disease, celiac and Wilson disease, coronary artery disease, kidney failure, hypothyroidism
Surgical treatment of obesity or severe weight loss
Presence of any other chronic disease or skeletal disorders

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
iver fat levels. Timepoint: Evaluation of fatty liver grade prior to the intervention and 24-48 h after intervention finished. Method of measurement: Using ultrasound (US).;Vitamin D levels. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling.;Anthropometric indices. Timepoint: Before the study starts and after the study ends. Method of measurement: Using INBODY test.;Lipid profile. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Serum levels of liver enzymes. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Glucose and insulin levels. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling.;Blood pressure. Timepoint: Before the study starts and after it ended. Method of measurement: Digital sphygmomanometer.

Secondary Outcome Measures