Effect of vitamin D supplementation on muscle strength and physical performance in knee osteoarthritis

Not Applicable

Completed

• Conditions: Knee Oa patients; vitamin D2 supplementation; knee osteoarthritis; muscle strength; physical performance

• Registration Number: TCTR20170324006
• Lead Sponsor: The 90th Anniversary Chulalongkorn University Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-01-05
• Study Start: 2017-03-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1.Knee OA patients who meet the criteria of American College of Rheumatology
2.Knee OA patients have vitamin D insufficiency (25(OH)D < 30 ng/ml)
3.Individuals capable of giving informed consent on their own behalf
4.Individuals willing to attend in this study

Exclusion Criteria

1.Knee OA patients who have history of knee surgery
2.Known primary hyperparathyroidism
3.Current supplement of vitamin D
4.Kidney disease
5.Liver disease
6.Rheumatoid or other inflammatory arthritis (i.e. septic arthritis, gout).
7.Neurological condition (i.e. Parkinson’s disease, previous stroke)
8.Severe cardiovascular condition (i.e. unstable angina)
9.Amputation of lower limbs
10.Unable to perform physical performance
11.Severe visual or hearing impairment uncorrected

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
25(OH)D levels baseline and 6 months after vitamin D2 supplementation blood sample collection

Secondary Outcome Measures

Name	Time	Method
muscle strength and physical performance baseline, 3 and 6 months after vitamin D2 supplementation muscle strength and physical performance tests