Effects of high dose vitamin D suppletion on muscle mass and muscle strength in frail elderly peolple.
- Conditions
- Hypovitaminosis DFrailtySarcopenia
- Registration Number
- NL-OMON21117
- Lead Sponsor
- Erasmus MC department of Geriatrics
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
1. Frail elderly people, age > 65;
2. Living in homes for the elderly;
3. Serum vitamin D level < 50 nmol/l
Exclusion Criteria
1. Not able to perform muscle strength measurements;
2. History of kidney stones, renal insufficiency (<40%);
3. Primary hyperparathyroidism;
4. Dementia (mini mental state examination < 20/30 points;
5. Life expectancy < 6 months;
6. Neurodegenerative disorders (M. Parkinson, ALS);
7. Use of the following medications: vitamin D, bisphosphonates, steroids.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in muscle strength (handgrip strength and m. quadriceps strength) between treatment and control group<br>
- Secondary Outcome Measures
Name Time Method 1. Changes in mobility<br>a. Timed up & go test<br>b. Walking distance<br>2. Quality of life<br>a. Health assessment questionnaire<br>3. Falls