eural adaptations to vitamin D supplementation in older adults: A pilot study

Phase 2

Completed

• Conditions: Falls; Sarcopenia; Vitamin D deficiency; Neurological - Studies of the normal brain and nervous system; Musculoskeletal - Other muscular and skeletal disorders; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12612000592842
• Lead Sponsor: Deakin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-06-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

Healthy older women (aged 60 years and over) with insufficient serum vitamin D levels (25-hydroxyvitamin D between 25 and 60 nmol/L) who are able to speak English proficiently and walk unaided or with minimal assistance (walking stick) for at least 50 m.

Exclusion Criteria

Participants will be ineligible based on the following: 1) current or prior participation in resistance exercise (greater or equal to once a week) and/or participating in greater than 150 min of physical activity per week in the past 3 months, 2) acute or terminal illness likely to compromise exercise testing, 3) unstable or ongoing cardiovascular/ respiratory disorders, 4) musculoskeletal or neurological diseases disrupting voluntary movement or that might limit testing, 5) upper or lower extremity fracture in the past 3 months, 6) visual impairment not corrected with glasses; 7) unable to follow instructions; and 8) currently taking vitamin D supplements (greater than 200 IU/d), and 9) not willing to take vitamin D supplements or placebo supplements for 3 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eural excitability and inhibition measured by Transcranial Magnetic Stimulation (TMS)[Meausrements will be made at baseline and 3 months];Muscle function (number of chair-rises within 30 s; 3-metre timed-up-and-go test, the four-square test, where subjects must step around four squares in one direction and back again)[Meausrements will be made at baseline and 3 months]

Secondary Outcome Measures

Name	Time	Method
Maximal muscle force (strength) and power for the muscles of the legs (Biodex machine)[Meausrements will be made at baseline and 3 months];Serum 25-hydroxyvitamin D[Meausrements will be made at baseline and 3 months];Health-related quality of life assessed by the SF-36 questionnaire[Meausrements will be made at baseline and 3 months];Cognitive function (mini-mental state examination)[Meausrements will be made at baseline and 3 months]